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The (bi)sexual brain

Uploader: Moogutaur 5 years ago  
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Other evidence supporting the role of testosterone and prenatal hormones in sexual orientation development include observations of male subjects with cloacal exstrophy who were sex-assigned as female during birth only later to declare themselves male. Both would take place during a limited time early in fetal development, both would be irreversible and both would generate separate organs or neural structures that enable copulation and mediate sex-specific behaviour. This animal model allows us to deconstruct the confounding properties of genotype-, sex hormone- and developmental-specificity mentioned above that plague conventional mammalian model systems. Despite this enormous diversity, there are strong similarities in the structure of the brain and the distribution of sex steroid hormone and peptide hormone receptors. Likewise, both sex hormones and genetic networks determine the sex-specific behaviour of males and females.

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